Positive or negative allosteric modulation of metabotropic glutamate receptor 5 ( mGluR 5 ) does not alter expression of behavioral sensitization to methamphetamine [ version 1 ; referees : 1 approved , 2 approved with reservations ]

We investigated the role of metabotropic glutamate receptor type 5 (mGluR5) in methamphetamine-induced behavioral sensitization. The mGluR5 positive allosteric modulator (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) and negative allosteric modulator fenobam were tested in separate experiments. Sprague-Dawley rats were repeatedly injected with 1 mg/kg methamphetamine or saline, and then given a locomotor challenge test using a dose of 0.5 mg/kg methamphetamine. Prior to the challenge test session, rats were injected with CDPPB, fenobam, or a vehicle. Doses from previous studies showed reduced drug-conditioned behavior; however in this study neither CDPPB nor fenobam pretreatment resulted in an altered expression of behavioral sensitization, indicating a lack of mGluR5 involvement in sensitized methamphetamine-induced locomotion. Additionally, the high dose (30 mg/kg) of fenobam resulted in decreased methamphetamine-induced locomotion in rats regardless of drug exposure history, which suggests evidence of nonspecific behavioral inhibition. Peter R Kufahl ( ) Corresponding author: [email protected] Kufahl PR, Nemirovsky NE, Watterson LR How to cite this article: et al. Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine [version 1; referees: 1 2013, :84 (doi: ) approved, 2 approved with reservations] F1000Research 2 10.12688/f1000research.2-84.v1 © 2013 Kufahl PR . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This work was completed with the support of NIH/NIDA grants DA025606 and DA024355 to MFO. Grant information: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: No relevant competing interests were disclosed. 12 Mar 2013, :84 (doi: ) First published: 2 10.12688/f1000research.2-84.v1 Referee Status: